Micky van de Ven Brace Halts The Toffees' Run at Brand New Home Ground
The Dutch defender became the initial backline player to net twice in a Premier League match for Tottenham since the Belgian defender in March 2013.
At a glance
Micky Van de Ven nods into the net two times in first half
The home side's defender has goal ruled after VAR review
Senegalese midfielder scores final goal in dying moments
This loss is the Merseyside club's first at Hill Dickinson Stadium
The Tottenham defender found the net on two occasions as Tottenham prolonged their unbeaten run on the road in the top division and delivered the Toffees their first defeat at their new home.
The Toffees were unbeaten in their last five matches at their recently opened stadium at Bramley-Moore Dock, having left their historic home behind after more than a century at the conclusion of last season.
But Tottenham's leader the Dutchman pounced twice from set-pieces in the first half to put their impressive record at risk, and they were failed to mount a comeback before Pape Matar Sarr - set up by former Toffees attacker Richarlison - headed home a third to put the game to bed.
The Everton defender believed he had equalized the tally five minutes after Van de Ven's opener, directing a bullet header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, meanwhile, missed a handful of opportunities, while the Italian goalkeeper made a succession of excellent saves to guarantee the London club went five away games without defeat in the English top flight.
But the VAR stepped in, instructing Craig Pawson to check the score on the pitchside monitor and the referee decided that the winger and the attacker were in an illegal position and had impeded with the Spurs keeper.
The win moves the manager's team into third place in the division, five points off north London rivals and leaders the Gunners.
Everton remain 14th and are six points ahead of the relegation zone.
Spurs breakdown: Van de Ven excels in duties at both ends of pitch
Following a drab midweek display in the Champions League against Monaco, where they mustered a only attempts on target, the manager chose Randal Kolo Muani up front instead of ex-Everton forward Richarlison.
The summer signing was unable to influence the game before being replaced for Richarlison after 60 minutes on the pitch, but it turns out he wasn't needed in the end.
Centre-back the Dutchman transformed into an offensive threat to be reckoned with.
Spurs' first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur directing the ball toward the six-yard box for an unmarked Van de Ven to head home.
And Ven de Ven - stepping up as captain in the Argentine's absence - notched his next goal in first-half stoppage time as he rose above Jordan Pickford to head home.
The Dutchman was just as impressive in defence, combining effectively with his defensive colleague as the pair handled excellently with the numerous deliveries thrown their way by the opposition.
Everton analysis: Toffees lacking finishing touch
The club's recent stadium had been a fortress, but it seems the novelty may have worn off somewhat and fans headed to the gates after Sarr's third for Tottenham.
The end in Everton's unbeaten home run won't be a major concern for David Moyes, but their striker situation will be.
Beto and the other striker - the Everton's two established strikers - had scored only a single goal combined before Sunday's match.
And they were failed to add to that miserable tally on a wet and gloomy evening on in Liverpool.
Beto's form was summed up when he opted to overhead kick a clear chance from close range, despite having room and time to reposition for a more conventional shot that would have tested Vicario.
Barry, too, was unable to make an impact after replacing Beto in the 65th minute.
It was not for a lack of opportunity. Most of Everton's offensive moves came through the winger and the forward, who relentlessly delivered threatening crosses into the Spurs box.
What next for these two sides?
The Toffees: The team travel to Sunderland in the Premier League on early November at 8 PM.
Tottenham: The London club travel to St James' Park on late October for their fourth-round Carabao Cup match against Newcastle.